Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14093510 | 0.79 | NOS2 (0.53) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL1824026 | 0.78 | NOS2 (0.53) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL14117381 | 0.78 | NOS2 (0.57) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL14291059 | 0.77 | NOS2 (0.96) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL20675953 | 0.77 | NOS2 (0.96) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL45769 | 0.76 | GRIN2B (0.68) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL4737504 | 0.75 | NOS2 (0.92) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| Amphetamine SCHEMBL28092355 | 0.74 | TAAR1 (0.66) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL2298200 | 0.74 | GRIN2B (0.54) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL4629266 | 0.74 | GRIN2B (0.72) | NOS2GRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | NOS2 176/4885GRIN2B 1547/4885GRIN1 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.