Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755089 | 1.00 | KMT2A (0.35) | KMT2AHPGDRORCOPRD1OPRM1 | |
| Hydrochloric Acid SCHEMBL5616268 | 0.99 | KMT2A (0.34) | KMT2AHPGDRORCOPRD1OPRM1 | |
| Hydrochloric Acid SCHEMBL757174 | 0.99 | KMT2A (0.34) | KMT2AHPGDRORCOPRD1OPRM1 | |
| SCHEMBL757090 | 0.91 | MAPT (0.36) | KMT2AHPGDOPRD1OPRM1OPRK1 | |
| SCHEMBL757580 | 0.91 | MAPT (0.36) | KMT2AHPGDOPRD1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL755877 | 0.90 | MAPT (0.35) | KMT2AHPGDOPRD1OPRM1OPRK1 | |
| SCHEMBL764691 | 0.89 | ADORA3 (0.40) | OPRD1OPRM1OPRK1OPRL1ADORA3 | |
| SCHEMBL755429 | 0.80 | BACE1 (0.34) | OPRD1OPRM1OPRL1ADORA3ADORA1 | |
| SCHEMBL760030 | 0.80 | BACE1 (0.34) | OPRD1OPRM1OPRL1ADORA3ADORA1 | |
| SCHEMBL755862 | 0.80 | BACE1 (0.34) | OPRD1OPRM1OPRL1ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007011833-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | claimed |
| WO-2007011810-A1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | claimed |