Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757090 | 1.00 | MAPT (0.36) | MAPTLMNATP53CASP3DRD2 | |
| Hydrochloric Acid SCHEMBL755877 | 0.99 | MAPT (0.35) | MAPTLMNATP53CASP3DRD2 | |
| SCHEMBL4740733 | 0.91 | KMT2A (0.35) | MAPTLMNAMEN1KMT2AOPRD1 | |
| SCHEMBL755089 | 0.91 | KMT2A (0.35) | MAPTLMNAMEN1KMT2AOPRD1 | |
| Hydrochloric Acid SCHEMBL757174 | 0.90 | KMT2A (0.34) | MEN1KMT2AOPRD1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL5616268 | 0.90 | KMT2A (0.34) | MEN1KMT2AOPRD1OPRM1OPRK1 | |
| SCHEMBL764691 | 0.90 | ADORA3 (0.40) | OPRD1OPRM1OPRK1OPRL1ADORA3 | |
| SCHEMBL765887 | 0.81 | BACE1 (0.41) | TP53MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL755429 | 0.81 | BACE1 (0.34) | OPRD1OPRM1OPRL1ADORA3ADORA2A | |
| SCHEMBL760030 | 0.81 | BACE1 (0.34) | OPRD1OPRM1OPRL1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-B1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | claimed |