SCHEMBL474143

SCHEMBL474143

CCOC(=O)N(c1ccc(CNC(=O)OC(C)(C)C)cc1C(=O)OC)C1CCN(C(=O)O)CC1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
ALDH1A1 P00352 3/20 0.38
TSHR P16473 1/20 0.38
GPR119 Q8TDV5 2/20 0.37
NAMPT P43490 1/20 0.35
LMNA P02545 2/20 0.35
POLB P06746 1/20 0.35
TP53 P04637 3/20 0.34
TDP1 Q9NUW8 1/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
EED O75530 1/20 0.34
RBBP4 Q09028 1/20 0.34
SUZ12 Q15022 1/20 0.34
EZH2 Q15910 1/20 0.34
AEBP2 Q6ZN18 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL136862 0.90 HTT (0.43) MEN1KMT2AGPR119LMNATP53
SCHEMBL474154 0.77 ALDH1A1 (0.40) ALDH1A1NAMPTLMNA
SCHEMBL14775699 0.72 ALDH1A1 (0.40) MEN1KMT2AALDH1A1TSHRNAMPT
SCHEMBL7930745 0.71 TSHR (0.46) ALDH1A1TSHRNAMPTLMNAKDM4E
SCHEMBL30965061 0.71 TSHR (0.46) ALDH1A1TSHRNAMPTLMNAKDM4E
SCHEMBL1205921 0.70 TSHR (0.47) ALDH1A1TSHRNAMPTLMNAKDM4E
SCHEMBL30005739 0.69 KMT2A (0.50) KMT2AALDH1A1TSHRNAMPT
SCHEMBL1205923 0.69 TSHR (0.46) MEN1KMT2ATSHRNAMPTKDM4E
SCHEMBL474324 0.68 CACNA1B (0.41) LMNA
SCHEMBL135627 0.68 HTT (0.47) MEN1KMT2ALMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205593-B1 QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI SA (FR) 2016-01-13 EP disclosed
EP-2416777-B1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI SA (FR) 2014-11-12 EP disclosed
EP-2411009-B1 Therapeutic uses of quinazolinedione derivatives SANOFI SA (FR) 2013-03-20 EP disclosed
EP-2416777-A1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI (FR) 2012-02-15 EP disclosed
EP-2411009-A1 THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES SANOFI (FR) 2012-02-01 EP disclosed
WO-2010116090-A1 THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES SANOFI-AVENTIS (FR) 2010-10-14 WO disclosed
WO-2010109148-A1 THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES SANOFI-AVENTIS (FR) 2010-09-30 WO disclosed