Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474154 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNANAMPTMAPTL3MBTL1 | |
| SCHEMBL9930974 | 0.74 | PTGES (0.43) | ALDH1A1LMNANAMPTTSHRMAPT | |
| SCHEMBL474143 | 0.72 | MEN1 (0.38) | ALDH1A1LMNANAMPTTSHRPOLB | |
| SCHEMBL135627 | 0.71 | HTT (0.47) | LMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL1205921 | 0.70 | TSHR (0.47) | ALDH1A1LMNANAMPTTSHRMAPT | |
| SCHEMBL30965061 | 0.69 | TSHR (0.46) | ALDH1A1LMNANAMPTTSHRMAPT | |
| SCHEMBL7930745 | 0.69 | TSHR (0.46) | ALDH1A1LMNANAMPTTSHRMAPT | |
| SCHEMBL6187601 | 0.69 | CTSK (0.56) | PARP1NAMPTKCNA3CKS1BSKP1 | |
| SCHEMBL6629351 | 0.68 | ROCK2 (0.46) | NAMPTTSHRL3MBTL1 | |
| SCHEMBL14969490 | 0.68 | TSHR (0.57) | ALDH1A1LMNANAMPTTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205593-B1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-01-13 | — | — | EP | disclosed |
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |