Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544207 | 0.78 | HTR6 (0.55) | ALDH1A1HSD17B10TDP1KDM4EMAPT | |
| SCHEMBL127246 | 0.77 | F2 (0.57) | ALDH1A1LMNAKMT2ACA12CA1 | |
| SCHEMBL18025296 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TDP1KDM4EMAPT | |
| SCHEMBL6172350 | 0.76 | HTR6 (0.52) | ALDH1A1HSD17B10TDP1KDM4EMAPT | |
| SCHEMBL3520533 | 0.76 | CA1 (0.55) | ALDH1A1HSD17B10TDP1KDM4EMAPT | |
| SCHEMBL6363790 | 0.75 | ALDH1A1 (0.57) | ALDH1A1HSD17B10KDM4EMAPTKMT2A | |
| SCHEMBL5441568 | 0.75 | ALDH1A1 (0.48) | ALDH1A1HSD17B10TDP1KDM4EMAPT | |
| SCHEMBL7301352 | 0.75 | F2 (0.55) | ALDH1A1TDP1MAPTCA12CA1 | |
| SCHEMBL7303158 | 0.75 | F2 (0.55) | ALDH1A1KMT2ACA1CA2TSHR | |
| SCHEMBL5234947 | 0.75 | KMT2A (0.35) | ALDH1A1MAPTLMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 320 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708344-B2 | Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease | HOFFMANN-LA ROCHE INC. (US) | 2023-07-25 | — | — | US | claimed |
| US-20230074887-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2023-03-09 | — | — | US | claimed |
| CN-113754541-A | Micromolecule inhibitor targeting EB virus nuclear antigen protein, preparation method and application thereof | 深圳湾实验室 | 2021-12-07 | — | — | CN | claimed |
| EP-3860984-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-08-11 | — | — | EP | claimed |
| CN-112912371-A | Flavone derivatives for treating and preventing hepatitis B virus diseases | 豪夫迈·罗氏有限公司 | 2021-06-04 | — | — | CN | claimed |
| CN-107033157-B | Bisbenzylisoquinoline derivative and application thereof in preparing medicament for treating or preventing tumor | 贵州省中国科学院天然产物化学重点实验室 | 2020-05-05 | — | — | CN | claimed |
| WO-2020070088-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-09 | — | — | WO | claimed |
| US-10189812-B2 | Bi-benzyl isoquinoline derivative, preparation method and use thereof in hepatopathy treatment and prevention | THE KEY LABORATORY OF CHEMISTRY FOR NATURAL PRODUC (CN) | 2019-01-29 | — | — | US | claimed |
| US-20170260161-A1 | BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION | VERSITECH LIMITED (CN) | 2017-09-14 | — | — | US | claimed |
| US-8440830-B2 | Tetrahydro-fused pyridines as histone deacetylase inhibitors | 4SC AG (DE) | 2013-05-14 | — | — | US | claimed |
| EP-0089004-A1 | Process for dyeing fibrous material from natural polyamides | CIBA-GEIGY AG (CH) | 1983-09-21 | — | — | EP | claimed |
| US-4400317-A | NO NEED TO PRECIPITATE PRODUCT FROM REACTION SOLUTION | AMERICAN HOECHST CORPORATION (US) | 1983-08-23 | — | — | US | claimed |
| EP-0062607-A2 | Monoazo dyestuffs, their praparation and their use | CIBA-GEIGY AG (CH) | 1982-10-13 | — | — | EP | claimed |
| EP-0042357-A2 | Azo dyes, their preparation and use | CIBA-GEIGY AG (CH) | 1981-12-23 | — | — | EP | claimed |
| US-4260540-A | SPIN DYEING POLYACRYLONITRILE | BAYER AKTIENGESELLSCHAFT (DE) | 1981-04-07 | — | — | US | claimed |
| US-4225489-A | Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties | BAYER AKTIENGESELLSCHAFT (DE) | 1980-09-30 | — | — | US | claimed |
| US-4008211-A | Betainic azo dyestuffs containing cobalt in complex union with a colorless, tridentate ligand | CIBA-GEIGY AG (CH) | 1977-02-15 | — | — | US | claimed |
| US-3980673-A | INSECTICIDES, ACARICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | claimed |
| US-3966704-A | Naphthylazo naphthyl copper complex dyestuffs | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | claimed |
| US-3933785-A | Azo compounds | CIBA-GEIGY AG (CH) | 1976-01-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260161-A1 | BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION | SLC10A1, SLC10A2, CYP4B1 | ALDH1A1 1187/4885HSD17B10 720/4885TDP1 3632/4885 |
| US-11708344-B2 | Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease | CCNE2, CCNE1, CCNT1 | ALDH1A1 455/4885HSD17B10 902/4885TDP1 3220/4885 |
| US-20230074887-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | CCNE2, CCNE1, CCNT1 | ALDH1A1 455/4885HSD17B10 902/4885TDP1 3220/4885 |
| US-10189812-B2 | Bi-benzyl isoquinoline derivative, preparation method and use thereof in hepatopathy treatment and prevention | SLC10A1, SLC10A2, CYP4B1 | ALDH1A1 1187/4885HSD17B10 720/4885TDP1 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.