Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738310 | 0.87 | ALDH1A1 (0.71) | NPC1RAB9AKMT2AADORA1KDM4E | |
| SCHEMBL4737640 | 0.84 | KDM4E (0.63) | MEN1NPC1RAB9AKMT2ARXFP1 | |
| SCHEMBL14148529 | 0.82 | KDM4E (0.58) | MEN1NPC1RAB9AKMT2ARXFP1 | |
| SCHEMBL4737628 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1MAPT | |
| SCHEMBL4737623 | 0.81 | KDM4E (0.60) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL235277 | 0.79 | ADORA1 (0.78) | MEN1NPC1RAB9AKMT2ARXFP1 | |
| SCHEMBL14148658 | 0.79 | LMNA (0.76) | MEN1NPC1RAB9AKMT2AADORA1 | |
| SCHEMBL6436649 | 0.78 | MAPT (0.53) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL977661 | 0.78 | CDC7 (0.70) | MEN1NPC1RAB9AKMT2ARXFP1 | |
| SCHEMBL4268936 | 0.77 | KDM4E (0.77) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |