Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738310 | 0.90 | ALDH1A1 (0.71) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4737623 | 0.87 | KDM4E (0.60) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4737628 | 0.85 | KDM4E (0.64) | KDM4EMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4741747 | 0.84 | MEN1 (0.65) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL4268936 | 0.80 | KDM4E (0.77) | KDM4EMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4737632 | 0.80 | KDM4E (0.62) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL14148402 | 0.79 | KDM4E (0.61) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4740896 | 0.78 | LMNA (0.56) | KDM4EMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL14148384 | 0.77 | KDM4E (0.73) | KDM4EMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14148528 | 0.77 | KDM4E (0.68) | KDM4EMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |