Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.64 |
| ▸ | CDC7 | O00311 | 5/20 | 0.59 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738310 | 0.92 | ALDH1A1 (0.71) | KDM4EALDH1A1MAPTTBK1CDC7 | |
| SCHEMBL4737632 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1MAPTTBK1CDC7 | |
| SCHEMBL4737623 | 0.86 | KDM4E (0.60) | KDM4EALDH1A1MAPTTBK1CDC7 | |
| SCHEMBL4737640 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1MAPTTBK1HTT | |
| SCHEMBL4741747 | 0.82 | MEN1 (0.65) | KDM4EALDH1A1MAPT | |
| SCHEMBL4268936 | 0.81 | KDM4E (0.77) | KDM4EALDH1A1MAPTCDC7DBF4 | |
| SCHEMBL14148402 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL14148384 | 0.79 | KDM4E (0.73) | KDM4EALDH1A1MAPTTBK1CDC7 | |
| SCHEMBL14059194 | 0.78 | TBK1 (1.00) | TBK1IKBKE | |
| SCHEMBL14148405 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |