Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741122 | 0.84 | TYMS (0.55) | NPY5RADORA1ADORA2ATYMSADORA2B | |
| SCHEMBL4741268 | 0.76 | TYMS (0.57) | NPY5RADORA1ADORA2ATYMSKDM4E | |
| SCHEMBL4739002 | 0.69 | TYMS (0.51) | NPY5RADORA1ADORA2ATYMSKDM4E | |
| SCHEMBL6835181 | 0.68 | NPY5R (0.49) | NPY5RTYMSKDM4EL3MBTL1MAPK1 | |
| SCHEMBL6835533 | 0.67 | NPY5R (1.00) | NPY5RTYMSKDM4EMAPTALDH1A1 | |
| SCHEMBL14148145 | 0.66 | MAPT (0.50) | ADORA1ADORA2ATYMSMAPTIGF1R | |
| SCHEMBL4741223 | 0.66 | TYMS (0.62) | TYMSKDM4EMAPTALDH1A1MPI | |
| SCHEMBL2340188 | 0.65 | ALDH1A1 (0.62) | NPY5RALDH1A1MAPK14LMNA | |
| SCHEMBL6652286 | 0.64 | TYMS (1.00) | TYMS | |
| SCHEMBL12567895 | 0.64 | NPY5R (0.57) | NPY5RKDM4EMAPTALDH1A1MPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |