Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30269796 | 1.00 | KDM4E (0.63) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL28281972 | 0.86 | KDM4E (0.67) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL7169528 | 0.84 | KDM4E (0.61) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL24196940 | 0.83 | KDM4E (0.54) | KDM4ELMNAL3MBTL1HPGDALDH1A1 | |
| SCHEMBL5289613 | 0.82 | DRD2 (0.59) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL27408412 | 0.81 | KDM4E (0.56) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL29580772 | 0.81 | KDM4E (0.78) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL42002 | 0.81 | KDM4E (0.78) | KDM4ELMNATP53L3MBTL1GAA | |
| SCHEMBL24960989 | 0.81 | KDM4E (0.56) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL6533183 | 0.81 | DRD2 (0.58) | KDM4ELMNATP53L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963292-A2 | ORGANIC COMPOUNDS | Novartis Pharma AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067615-A2 | THIADIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS | NOVARTIS AG (CH) | 2007-06-14 | — | — | WO | disclosed |