Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679794 | 0.85 | LMNA (0.61) | POLBALDH1A1MAPTTP53BP1NPSR1 | |
| SCHEMBL4002713 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPTNPSR1LMNANAMPT | |
| SCHEMBL30739602 | 0.80 | POLB (0.78) | POLBALDH1A1TP53BP1TAS1R3TAS1R1 | |
| SCHEMBL2855037 | 0.80 | POLB (0.78) | POLBALDH1A1TP53BP1TAS1R3TAS1R1 | |
| SCHEMBL29658300 | 0.79 | POLB (0.64) | POLBALDH1A1TP53BP1HDAC2NAMPT | |
| SCHEMBL3770723 | 0.79 | POLB (0.57) | POLBALDH1A1CHRM3CHRM4CHRM5 | |
| SCHEMBL6360091 | 0.77 | POLB (1.00) | POLBALDH1A1TP53BP1TAS1R3TAS1R1 | |
| SCHEMBL12465462 | 0.76 | CCR2 (0.80) | CCR2 | |
| SCHEMBL4006239 | 0.76 | DRD2 (0.73) | CCR2 | |
| SCHEMBL1420613 | 0.76 | CHRM4 (0.67) | CHRM3CHRM4CHRM5CHRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981870-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092531-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-08-16 | — | — | WO | disclosed |