SCHEMBL474238

SCHEMBL474238

CCc1cccc2c(O)ccnc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.50
LMNA P02545 3/20 0.50
MAPT P10636 2/20 0.50
ALOX12 P18054 2/20 0.50
TP53 P04637 1/20 0.50
TSHR P16473 1/20 0.50
GABRA1 P14867 1/20 0.45
GABRB2 P47870 1/20 0.45
COMT P21964 1/20 0.44
L3MBTL1 Q9Y468 5/20 0.44
RAB9A P51151 3/20 0.44
KDM4A O75164 1/20 0.44
EGLN1 Q9GZT9 1/20 0.44
HIF1AN Q9NWT6 1/20 0.44
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
NPC1 O15118 3/20 0.42
HTT P42858 3/20 0.42
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19725754 0.83 KDM4E (0.50) KDM4ELMNAMAPTALOX12TP53
SCHEMBL12557727 0.82 KDM4E (0.54) KDM4ELMNAMAPTALOX12TP53
SCHEMBL3272867 0.80 PSMD14 (0.58) KDM4ELMNAMAPTALOX12TP53
SCHEMBL22492368 0.79 GABRA1 (0.45) KDM4ELMNAMAPTALOX12TP53
SCHEMBL1714724 0.79 KDM4E (0.74) KDM4ELMNAMAPTALOX12TP53
SCHEMBL22492438 0.78 KDM4E (0.64) KDM4ELMNAMAPTALOX12TP53
SCHEMBL20415138 0.77 ELANE (0.39) KDM4ELMNAMAPTALOX12TP53
SCHEMBL1333120 0.77 KDM4E (0.66) KDM4ELMNAMAPTALOX12TP53
SCHEMBL30668494 0.77 KDM4E (0.66) KDM4ELMNAMAPTALOX12TP53
SCHEMBL3691358 0.76 HTR1A (0.45) KDM4ELMNAMAPTALOX12TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2112206-B1 Polymer Composition ROHM & HAAS (US) 2016-06-29 EP disclosed
EP-2166043-B1 Thickener composition and method for thickening aqueous systems ROHM & HAAS (US) 2016-04-27 EP disclosed
CN-101676342-B Thickened compositions and method for thickening aqueous polymer compositions ROHM & HAAS 2013-05-01 CN disclosed
CN-101676332-B Thickener composition and method for thickening aqueous systems ROHM & HAAS 2012-06-27 CN disclosed
EP-1771453-B1 HEPATITIS C INHIBITOR DIPEPTIDE ANALOGS BOEHRINGER INGELHEIM INT (DE) 2012-05-30 EP disclosed
EP-2166044-B1 Thickened compositions and method for thickening aqueous polymer compositions ROHM & HAAS (US) 2012-02-01 EP disclosed
US-20110281980-A1 Thickener composition and method for thickening aqueous systems BOBSEIN BARRETT RICHARD (US) 2011-11-17 US disclosed
US-8034869-B2 Thickened compositions and method for thickening aqueous polymer compositions ROHM AND HAAS COMPANY (US) 2011-10-11 US disclosed
US-7985795-B2 Thickener composition and method for thickening aqueous systems ROHM AND HAAS COMPANY (US) 2011-07-26 US disclosed
EP-1972665-B1 Thickener composition and method for thickening aqueous systems ROHM & HAAS (US) 2011-04-27 EP disclosed
US-20100227953-A1 Thickened compositions and method for thickening aqueous polymer compositions ROHM AND HAAS COMPANY 2010-09-09 US disclosed
US-7741402-B2 Thickener composition and method for thickening aqueous systems ROHM AND HAAS COMPANY (US) 2010-06-22 US disclosed
US-20100076145-A1 Thickener composition and method for thickening aqueous systems ROHM AND HAAS COMPANY 2010-03-25 US disclosed
EP-2166044-A1 Thickened compositions and method for thickening aqueous polymer compositions Rohm and Haas Company (US) 2010-03-24 EP disclosed
EP-2166043-A2 Thickener composition and method for thickening aqueous systems Rohm and Haas Company (US) 2010-03-24 EP disclosed
CN-101676332-A Thickener composition and method for thickening aqueous systems ROHM & HAAS 2010-03-24 CN disclosed
CN-101676342-A Thickened compositions and method for thickening aqueous polymer compositions ROHM & HAAS 2010-03-24 CN disclosed
EP-2112206-A1 Polymer Composition Rohm and Haas Company (US) 2009-10-28 EP disclosed
US-20080234411-A1 Thickener composition and method for thickening aqueous systems ROHM AND HAAS COMPANY 2008-09-25 US disclosed
EP-1972665-A2 Thickener composition and method for thickening aqueous systems Rohm and Haas Company (US) 2008-09-24 EP disclosed