Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474230 | 0.85 | GPR119 (0.46) | GPR119LIMK2 | |
| SCHEMBL12432537 | 0.80 | OPRD1 (0.47) | HDAC4PDK2OPRM1OPRD1CYP11B2 | |
| SCHEMBL12432533 | 0.79 | HDAC4 (0.38) | HDAC4PDK2OPRM1OPRD1CYP11B2 | |
| SCHEMBL474258 | 0.78 | OPRD1 (0.38) | HDAC4PDK2OPRM1OPRD1CYP11B2 | |
| SCHEMBL474252 | 0.77 | OPRM1 (0.62) | HDAC4OPRM1OPRD1PDK1 | |
| SCHEMBL474189 | 0.74 | OPRD1 (0.46) | HDAC4PDK2OPRM1OPRD1 | |
| SCHEMBL21015888 | 0.71 | HDAC4 (0.46) | HDAC4PDK2PDK1PDK3PDK4 | |
| SCHEMBL19598956 | 0.71 | GPR119 (0.52) | GPR119 | |
| SCHEMBL1602493 | 0.69 | GPR119 (0.50) | GPR119OPRD1 | |
| SCHEMBL17843396 | 0.69 | OPRD1 (0.49) | OPRM1OPRD1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079735-B1 | N- (2 -HYDROXYETHYL) -N-METHYL- 4- (QUINOLIN- 8-YL (1- (THIAZOL-4- YLMETHYL) PIPERIDIN- 4 -YLIDENE) METHYL) BENZAMIDE, THE PROCESS OF MAKING IT AS WELL AS ITS USE FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | ASTRAZENECA AB (SE) | 2012-02-01 | — | — | EP | claimed |