Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12432537 | 0.87 | OPRD1 (0.47) | OPRD1OPRM1HDAC4PDK2CYP11B2 | |
| SCHEMBL12432533 | 0.86 | HDAC4 (0.38) | OPRD1OPRM1HDAC4PDK2ITGB3 | |
| SCHEMBL17847939 | 0.84 | ALDH1A1 (0.40) | OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL474189 | 0.81 | OPRD1 (0.46) | OPRD1OPRM1HDAC4PDK2OPRK1 | |
| SCHEMBL474239 | 0.78 | HDAC4 (0.35) | OPRD1OPRM1HDAC4PDK2CYP11B2 | |
| SCHEMBL17843396 | 0.75 | OPRD1 (0.49) | OPRD1OPRM1ACHEALDH1A1 | |
| SCHEMBL10795881 | 0.74 | HDAC4 (0.54) | HDAC4PDK2CYP11B2DRD2MCHR1 | |
| SCHEMBL474620 | 0.73 | OPRD1 (0.70) | OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL22922406 | 0.70 | CDK4 (0.51) | HDAC4PDK2DRD2MAPTRHEB | |
| SCHEMBL1004454 | 0.70 | KMT2A (0.51) | HDAC4PDK2ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079735-B1 | N- (2 -HYDROXYETHYL) -N-METHYL- 4- (QUINOLIN- 8-YL (1- (THIAZOL-4- YLMETHYL) PIPERIDIN- 4 -YLIDENE) METHYL) BENZAMIDE, THE PROCESS OF MAKING IT AS WELL AS ITS USE FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | ASTRAZENECA AB (SE) | 2012-02-01 | — | — | EP | claimed |
| WO-2016099394-A1 | NOVEL SELECTIVE DELTA-OPIOID RECEPTOR AGONISTS USEFUL FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | PHARMNOVO AB (SE) | 2016-06-23 | — | — | WO | disclosed |