Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096865 | 0.94 | KEAP1 (0.54) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL7744005 | 0.92 | HDAC1 (0.56) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL9672257 | 0.89 | ALDH1A1 (0.58) | KEAP1NFE2L2HDAC1HDAC8HDAC3 | |
| SCHEMBL1779667 | 0.86 | PSIP1 (0.56) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL10629823 | 0.86 | PSIP1 (0.61) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL576918 | 0.86 | KEAP1 (0.63) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL10626503 | 0.84 | HDAC1 (0.65) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL777601 | 0.81 | PSIP1 (0.67) | PSIP1KEAP1NFE2L2HDAC1HDAC8 | |
| SCHEMBL5387555 | 0.81 | PLCG1 (0.59) | HSD11B1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8972497 | 0.80 | PSIP1 (0.54) | PSIP1KEAP1NFE2L2HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014426-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS (US) | 2016-01-28 | — | — | WO | disclosed |
| CN-103509135-B | Olefin polymerization catalyst component, preparation method and application thereof | CHINA PETROLEUM & CHEMICAL | 2015-07-22 | — | — | CN | disclosed |
| CN-101252929-A | G protein-coupled receptor agonists | PROSIDION LTD (GB) | 2008-08-27 | — | — | CN | disclosed |
| WO-2008096128-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES 2 | ARGENTA DISCOVERY LTD (GB) | 2008-08-14 | — | — | WO | disclosed |
| US-6051605-A | TREATING PSYCHOSIS AND SCHIZOPHRENIA USING A COMPOUND THAT IS AN ANTAGONIST OF DOPAMINE D4 RECEPTORS | WARNER-LAMBERT COMPANY (US) | 2000-04-18 | — | — | US | disclosed |
| US-4775674-A | CARDIOTONIC AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-10-04 | — | — | US | disclosed |