Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742621 | 0.92 | USP2 (0.45) | MAPTPTPN11ACHECKS1BSKP1 | |
| SCHEMBL4743406 | 0.90 | MET (0.39) | MAPTPTPN11ACHECKS1BSKP1 | |
| SCHEMBL4785479 | 0.85 | THRB (0.42) | MAPTPTPN11GPR119CKS1BSKP1 | |
| SCHEMBL4739339 | 0.80 | MET (0.46) | MAPTPTPN11THRBKITLMNA | |
| SCHEMBL4743456 | 0.80 | MAPT (0.47) | MAPTPTPN11ACHEGPR119CKS1B | |
| SCHEMBL4742558 | 0.79 | USP2 (0.44) | MAPTPTPN11ACHECKS1BSKP1 | |
| SCHEMBL4743039 | 0.79 | USP2 (0.35) | MAPTTP53USP2MAPK1RECQL | |
| SCHEMBL4741642 | 0.78 | MAPT (0.64) | MAPTTP53USP2MAPK1RECQL | |
| SCHEMBL4786909 | 0.77 | MET (0.39) | MAPTPTPN11ACHETP53BACE1 | |
| SCHEMBL4785468 | 0.72 | THRB (0.45) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008093940-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION PROCESS FOR THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2008-08-07 | — | — | WO | disclosed |