Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.73 |
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | VCP | P55072 | 2/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.67 |
| ▸ | CFTR | P13569 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.64 |
| ▸ | RELA | Q04206 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | AGER | Q15109 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588861 | 0.85 | CFTR (0.73) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL486534 | 0.82 | ALOX5 (0.82) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL4742547 | 0.81 | ALOX5 (1.00) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL30060152 | 0.77 | MBD2 (1.00) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL13390238 | 0.77 | MBD2 (1.00) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL7114964 | 0.77 | ALOX5 (1.00) | MEN1KMT2AMAPTVCPALOX5 | |
| SCHEMBL7115473 | 0.77 | ALOX5 (0.73) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL4536179 | 0.76 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL3049195 | 0.76 | KMT2A (0.66) | MEN1KMT2AMAPTALDH1A1VCP | |
| SCHEMBL18221589 | 0.75 | MEN1 (0.65) | MEN1KMT2AMAPTALDH1A1VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101029-A2 | USE OF THIAZOLE, OXAZOLE AND IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-21 | — | — | WO | claimed |
| US-20170066759-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2017-03-09 | — | — | US | disclosed |
| US-9499533-B2 | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity | SHIONOGI & CO., LTD. (JP) | 2016-11-22 | — | — | US | disclosed |
| US-20150038483-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-02-05 | — | — | US | disclosed |
| EP-2832731-A1 | AROMATIC HETEROCYCLIC FIVE-MEMBERED RING DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2015-02-04 | — | — | EP | disclosed |
| WO-2008101029-A2 | USE OF THIAZOLE, OXAZOLE AND IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066759-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | TRPV4, TRPC4, TRPV2 | MEN1 3938/4885KMT2A 1257/4885MAPT 4306/4885 |
| US-20150038483-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | TRPV4, TRPC4, TRPV2 | MEN1 3938/4885KMT2A 1257/4885MAPT 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.