Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBD2 | Q9UBB5 | 2/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.74 |
| ▸ | VCP | P55072 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.72 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.72 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.70 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13390238 | 1.00 | MBD2 (1.00) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL1890717 | 0.85 | MAPT (0.74) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL1887374 | 0.85 | VCP (1.00) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL12639826 | 0.84 | SMN1; SMN2 (1.00) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL4742547 | 0.82 | ALOX5 (1.00) | MBD2VCPMAPTMEN1KMT2A | |
| SCHEMBL17071970 | 0.82 | KCNN1 (0.73) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL7678939 | 0.81 | MAPT (0.81) | MBD2NR4A1VCPMAPTMEN1 | |
| SCHEMBL486534 | 0.81 | ALOX5 (0.82) | MBD2VCPMAPTMEN1KMT2A | |
| SCHEMBL23553573 | 0.81 | NPY5R (0.76) | MBD2NR4A1VCPMAPTMEN1 | |
| Bromide SCHEMBL7673197 | 0.80 | MAPT (0.79) | MBD2NR4A1VCPMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12419900-B2 | Induction of synthetic lethality with epigenetic therapy | THE JOHNS HOPKINS UNIVERSITY (US) | 2025-09-23 | — | — | US | disclosed |
| US-20230100402-A1 | INDUCTION OF SYNTHETIC LETHALITY WITH EPIGENETIC THERAPY | THE JOHNS HOPKINS UNIVERSITY | 2023-03-30 | — | — | US | disclosed |
| US-11491174-B2 | Induction of synthetic lethality with epigenetic therapy | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11491174-B2 | Induction of synthetic lethality with epigenetic therapy | MCL1, BAD, ACIN1 | MBD2 219/4885NR4A1 3817/4885VCP 3269/4885 |
| US-20230100402-A1 | INDUCTION OF SYNTHETIC LETHALITY WITH EPIGENETIC THERAPY | MCL1, BAD, ACIN1 | MBD2 219/4885NR4A1 3817/4885VCP 3269/4885 |
| US-12419900-B2 | Induction of synthetic lethality with epigenetic therapy | MCL1, BAD, ACIN1 | MBD2 219/4885NR4A1 3817/4885VCP 3269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.