Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 5/20 | 0.56 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.56 |
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28769844 | 0.91 | P2RY1 (0.57) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL9394425 | 0.88 | P2RY1 (0.51) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| Phosphoric Acid SCHEMBL474409 | 0.87 | ADORA1 (0.48) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL30474605 | 0.85 | P2RY1 (0.49) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL2791981 | 0.85 | P2RY1 (0.59) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL30195073 | 0.85 | P2RY1 (0.59) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL16108838 | 0.85 | P2RY1 (0.59) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL219553 | 0.85 | ADORA3 (0.49) | SMN1; SMN2ADORA1 | |
| SCHEMBL16700549 | 0.85 | P2RY1 (0.58) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL10824472 | 0.84 | P2RY1 (0.60) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INST (US) | 2025-07-31 | — | — | US | disclosed |
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | THE WISTAR INSTITUTE (US) | 2025-04-22 | — | — | US | disclosed |
| US-20220281826-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE | 2022-09-08 | — | — | US | disclosed |
| CN-114466840-A | acetyl-CoA synthetase 2(ACSS2) inhibitors and methods of use thereof | 威斯达研究所 | 2022-05-10 | — | — | CN | disclosed |
| EP-3983391-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | The Wistar Institute (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020252407-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE (US) | 2020-12-17 | — | — | WO | disclosed |
| US-8518635-B2 | Regulation of protein activity by reversible acetylation | THE J. DAVID GLADSTONE INSTITUTES (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2029731-B1 | REGULATION OF PROTEIN ACTIVITY BY REVERSIBLE ACETYLATION | DAVID GLADSTONE INST (US) | 2012-02-01 | — | — | EP | disclosed |
| CN-101490250-A | Regulation of protein activity by reversible acetylation | DAVID GLADSTONE INST (US) | 2009-07-22 | — | — | CN | disclosed |
| US-20090061015-A1 | Regulation of Protein Activity By Reversible Acetylation | THE J. DAVID GLADSTONE INSTITUTES (US) | 2009-03-05 | — | — | US | disclosed |
| EP-2029731-A2 | REGULATION OF PROTEIN ACTIVITY BY REVERSIBLE ACETYLATION | The J. David Gladstone Institutes (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007149270-A9 | REGULATION OF PROTEIN ACTIVITY BY REVERSIBLE ACETYLATION | DAVID GLADSTONE INST (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2007149270-A2 | REGULATION OF PROTEIN ACTIVITY BY REVERSIBLE ACETYLATION | THE J. DAVID GLADSTONE INSTITUTES (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | ACSS2, ACACB, ACACA | P2RY1 4495/4885P2RY2 3879/4885SRC 2755/4885 |
| US-20220281826-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | ACSS2, ACACB, ACACA | P2RY1 4495/4885P2RY2 3879/4885SRC 2755/4885 |
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | ACSS2, ACACB, ACACA | P2RY1 4495/4885P2RY2 3879/4885SRC 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.