Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744549 | 0.90 | KMT2A (0.54) | KMT2APLOD2LMNAATMALDH1A1 | |
| SCHEMBL31326709 | 0.84 | KDM4E (0.64) | KMT2APLOD2LMNAALDH1A1MAPT | |
| SCHEMBL10664827 | 0.84 | KDM4E (0.64) | KMT2APLOD2LMNAALDH1A1MAPT | |
| SCHEMBL9310930 | 0.83 | PLOD2 (0.50) | KMT2APLOD2LMNAALDH1A1CYP1A2 | |
| SCHEMBL360711 | 0.83 | PLOD2 (0.69) | KMT2APLOD2LMNAALDH1A1TSHR | |
| SCHEMBL6501915 | 0.82 | RAB9A (0.66) | KMT2APLOD2LMNAALDH1A1MAPT | |
| SCHEMBL4745216 | 0.82 | THRB (0.50) | KMT2APLOD2LMNAATMALDH1A1 | |
| Bromide SCHEMBL11040809 | 0.82 | PLOD2 (0.67) | KMT2APLOD2LMNAALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL11169565 | 0.82 | PLOD2 (0.67) | KMT2APLOD2LMNAALDH1A1TSHR | |
| SCHEMBL4744539 | 0.80 | PLOD2 (0.56) | KMT2APLOD2LMNAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115141-A1 | 4, 5-DIHYDRO-1,3-THIAZOL-2-AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-09-25 | — | — | WO | disclosed |