Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023315 | 0.88 | ALPL (0.55) | ALPLTARBP2GABRA2GABRB2TP53 | |
| SCHEMBL4872475 | 0.86 | ALPL (0.49) | ALPLTARBP2GABRA2GABRB2TP53 | |
| SCHEMBL6852749 | 0.86 | KDM4E (0.57) | TARBP2GABRA2GABRB2RAB9AKDM4E | |
| SCHEMBL8368083 | 0.84 | ALPL (0.52) | ALPLTARBP2GABRA2GABRB2TP53 | |
| SCHEMBL8364844 | 0.84 | ALPL (0.46) | ALPLTARBP2GABRA2GABRB2GCGR | |
| SCHEMBL17803271 | 0.84 | MAPT (0.50) | TARBP2KDM4EHTTMAPK10SMN1; SMN2 | |
| SCHEMBL16197762 | 0.81 | ALPL (0.46) | ALPLRAB9AKDM4ESMN1; SMN2POLB | |
| SCHEMBL21331813 | 0.78 | KDM4E (0.55) | TARBP2RAB9AKDM4EHTTMAPK10 | |
| SCHEMBL10355412 | 0.78 | KDM4E (0.57) | ALPLTARBP2GABRA2GABRB2TP53 | |
| SCHEMBL2197641 | 0.76 | ALOX5 (0.51) | TARBP2ALOX5RAB9AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101860-A1 | NOVEL PROCESS FOR THE PREPARATION OF 5-(4-CHLOROPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METHYL-N-(PIPERIDIN-1-YL)PYRAZOLE-3-CARBOXAMIDE | SANDOZ AG (CH) | 2008-08-28 | — | — | WO | claimed |
| US-8367714-B2 | Cannabinoid receptor targeted agent | VANDERBILT UNIVERSITY (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367714-B2 | Cannabinoid receptor targeted agent | VANDERBILT UNIVERSITY (US) | 2013-02-05 | — | — | US | disclosed |
| US-20090105128-A1 | CANNABINOID RECEPTOR TARGETED AGENT | VANDERABILT UNIVERSITY | 2009-04-23 | — | — | US | disclosed |
| US-20090105128-A1 | CANNABINOID RECEPTOR TARGETED AGENT | VANDERABILT UNIVERSITY | 2009-04-23 | — | — | US | disclosed |
| WO-2009029727-A1 | CANNABINOID RECEPTOR TARGETED AGENT | VANDERBILT UNIVERSITY (US) | 2009-03-05 | — | — | WO | disclosed |
| EP-1725546-B1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | EP | disclosed |
| WO-2008101860-A1 | NOVEL PROCESS FOR THE PREPARATION OF 5-(4-CHLOROPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METHYL-N-(PIPERIDIN-1-YL)PYRAZOLE-3-CARBOXAMIDE | SANDOZ AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| US-7265149-B2 | Indolyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| US-20050203160-A1 | Indolyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-09-15 | — | — | US | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |
| US-5925768-A | ANTIINFLAMMATORY AGENTS; ANALGESICS, ANTICOAGULANTS, NARCOTICS | SANOFI (FR) | 1999-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105128-A1 | CANNABINOID RECEPTOR TARGETED AGENT | CNR1, CNR2, NPY1R | ALPL 4846/4885TARBP2 4592/4885GABRA2 91/4885 |
| US-20050203160-A1 | Indolyl derivatives | PPARD, PPARA, PPARG | ALPL 1940/4885TARBP2 3997/4885GABRA2 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.