Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898001 | 0.83 | AKR1B10 (0.45) | HDAC1HDAC6BACE1ESR1ESR2 | |
| SCHEMBL14625259 | 0.83 | SLC6A3 (0.47) | HDAC3HDAC1HDAC2HDAC6BACE1 | |
| SCHEMBL14625193 | 0.78 | SLC6A3 (0.51) | HDAC3HDAC1HDAC2HDAC6POLB | |
| SCHEMBL24746321 | 0.78 | ABCC9 (0.36) | SLC6A3SLC6A2SLC6A4IDO1 | |
| SCHEMBL1905906 | 0.78 | SLC6A4 (0.36) | ESR2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8418296 | 0.78 | POLB (0.45) | HDAC3HDAC1HDAC2HDAC6POLB | |
| SCHEMBL26607109 | 0.75 | ESR1 (0.36) | POLBESR1ESR2ACHECCR2 | |
| SCHEMBL257534 | 0.75 | SLC6A3 (0.49) | HDAC3HDAC1HDAC2HDAC6SLC6A3 | |
| SCHEMBL19507134 | 0.75 | SMN1; SMN2 (0.44) | HDAC3HDAC1HDAC2HDAC6POLB | |
| SCHEMBL24746227 | 0.75 | HDAC3 (0.49) | HDAC3HDAC1HDAC2HDAC6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
| WO-2017006283-A1 | DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING CYCLOPROPANO LINKAGE | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2017-01-12 | — | — | WO | disclosed |
| WO-2008104101-A1 | 1-(3-METHYL-4-FLUORO) PHENYL-1-METHYLCYCLOPROPANE COMPOUNDS AND USE THEREOF | SINOCHEM CORPORATION (CN) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008104101-A1 | 1-(3-METHYL-4-FLUORO) PHENYL-1-METHYLCYCLOPROPANE COMPOUNDS AND USE THEREOF | SINOCHEM CORPORATION (CN) | 2008-09-04 | — | — | WO | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |