Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787536 | 0.86 | ALDH1A1 (0.55) | TSHRALOX15MAPK1MAPTHTT | |
| SCHEMBL4746814 | 0.86 | TP53 (0.43) | TSHRALOX15MAPK1MAPTHTT | |
| SCHEMBL4786255 | 0.85 | L3MBTL1 (0.48) | TSHRALOX15MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL4787514 | 0.83 | L3MBTL1 (0.52) | TSHRALOX15HTTL3MBTL1GFER | |
| SCHEMBL4786573 | 0.83 | CCR1 (0.43) | TSHRALOX15MAPK1MAPTHTT | |
| SCHEMBL4785632 | 0.82 | TP53 (0.38) | MAPK1MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL5244145 | 0.81 | L3MBTL1 (0.50) | TSHRALOX15MAPK1L3MBTL1KMT2A | |
| SCHEMBL4742206 | 0.79 | ALDH1A1 (0.43) | MAPTHTTSMN1; SMN2TP53MEN1 | |
| SCHEMBL5242720 | 0.79 | ALDH1A1 (0.67) | TSHRALOX15MAPK1MAPTHTT | |
| SCHEMBL4784036 | 0.79 | TSHR (0.67) | TSHRALOX15HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |