Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 4/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11781294 | 0.86 | KDM4C (0.53) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL1515901 | 0.86 | HTT (0.57) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL29466481 | 0.86 | HTT (0.57) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL14610404 | 0.84 | ALOX5AP (0.53) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL3905291 | 0.83 | SLC6A3 (0.67) | ALOX5APFEN1SLC6A4SLC6A3CHEK1 | |
| SCHEMBL29466501 | 0.83 | SLC6A3 (0.67) | ALOX5APFEN1SLC6A4SLC6A3CHEK1 | |
| SCHEMBL17796931 | 0.83 | ALDH1A1 (0.48) | SLC6A4SLC6A3HTTMAPTSMN1; SMN2 | |
| SCHEMBL3236362 | 0.81 | BCAT2 (0.63) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL1515697 | 0.79 | ALOX5AP (0.59) | CTSAALOX5APFEN1SLC6A4SLC6A3 | |
| SCHEMBL30955031 | 0.78 | BCAT2 (0.57) | SLC6A4SLC6A3CHEK1KDM4CHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |