Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 6/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29035907 | 0.80 | CA1 (0.38) | CYP2D6CYP3A4MEN1KMT2ADRD1 | |
| SCHEMBL28267065 | 0.79 | PNMT (0.37) | CYP2D6CYP3A4MEN1KMT2ADRD1 | |
| SCHEMBL30804802 | 0.79 | ALDH1A1 (0.38) | CYP2D6CYP3A4MEN1KMT2ADRD1 | |
| SCHEMBL6920787 | 0.79 | CA1 (0.40) | CYP2D6CYP3A4MEN1KMT2ADRD1 | |
| SCHEMBL2695009 | 0.76 | ALDH1A1 (0.37) | ALDH1A1MAPTKDM4E | |
| SCHEMBL29383585 | 0.71 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTTP53LMNA | |
| SCHEMBL5708850 | 0.71 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTTP53LMNA | |
| SCHEMBL29644910 | 0.68 | HTR6 (0.42) | MEN1KMT2APKMTSHR | |
| SCHEMBL359802 | 0.67 | MAPK1 (0.42) | CYP2D6CYP3A4MEN1KMT2ADRD1 | |
| SCHEMBL9009806 | 0.64 | HTR2A (0.40) | CYP2D6CYP3A4MEN1KMT2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013016441-A1 | HIV INTEGRASE INHIBITORY OXOISOINDOLINE SULFONAMIDES | The United States of America, represented by The Secretary, Department of Health & Human Services (US) | 2013-01-31 | — | — | WO | claimed |
| WO-2013016441-A1 | HIV INTEGRASE INHIBITORY OXOISOINDOLINE SULFONAMIDES | The United States of America, represented by The Secretary, Department of Health & Human Services (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |