Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20286599 | 0.96 | ALOX5 (0.67) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL4746826 | 0.93 | ALOX5 (0.57) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL257205 | 0.87 | ALOX5 (0.57) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL4746819 | 0.86 | KARS1 (0.53) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL168009 | 0.85 | ALOX5 (0.55) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL4746026 | 0.85 | ADORA2A (0.49) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL8154046 | 0.82 | ALOX5 (0.52) | ALOX5ADORA3ADORA1ADORA2AHTT | |
| SCHEMBL168675 | 0.76 | RORB (0.46) | ALOX5LMNAMAPTPTGDR2 | |
| SCHEMBL23792103 | 0.68 | PTGDR2 (0.45) | ALOX5MAPTPTGDR2KARS1 | |
| SCHEMBL3873992 | 0.67 | ADORA2A (1.00) | ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |