Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746487 | 1.00 | HSD11B1 (0.39) | HSD11B1KCNH2SIGMAR1OPRM1 | |
| SCHEMBL4748815 | 0.82 | HSD11B1 (0.39) | HSD11B1KCNH2SIGMAR1OPRM1 | |
| SCHEMBL4746505 | 0.82 | HSD11B1 (0.39) | HSD11B1KCNH2SIGMAR1OPRM1 | |
| SCHEMBL4746540 | 0.78 | IDO1 (0.34) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4746538 | 0.78 | IDO1 (0.34) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4748978 | 0.72 | P2RX7 (0.39) | — | |
| SCHEMBL4788355 | 0.64 | HSD11B1 (0.44) | HSD11B1SIGMAR1 | |
| SCHEMBL25238827 | 0.64 | KCNH2 (0.30) | KCNH2 | |
| SCHEMBL25779511 | 0.63 | KCNH2 (0.31) | KCNH2 | |
| SCHEMBL31145949 | 0.63 | HSD11B1 (0.43) | HSD11B1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |