Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746540 | 1.00 | IDO1 (0.34) | IDO1TDO2HSD11B1ALDH1A1APLNR | |
| SCHEMBL4746488 | 0.78 | HSD11B1 (0.39) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4746505 | 0.78 | HSD11B1 (0.39) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4748815 | 0.78 | HSD11B1 (0.39) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4746487 | 0.78 | HSD11B1 (0.39) | HSD11B1SIGMAR1OPRM1 | |
| SCHEMBL4749155 | 0.77 | AAK1 (0.36) | — | |
| SCHEMBL4749154 | 0.77 | AAK1 (0.36) | — | |
| SCHEMBL4831699 | 0.72 | OPRM1 (0.46) | ALDH1A1APLNROPRM1 | |
| SCHEMBL4788355 | 0.70 | HSD11B1 (0.44) | IDO1TDO2HSD11B1SIGMAR1CES2 | |
| SCHEMBL31145949 | 0.68 | HSD11B1 (0.43) | IDO1TDO2HSD11B1SIGMAR1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |