Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18644548 | 0.81 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL6742429 | 0.79 | TSHR (0.58) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL9213101 | 0.79 | TSHR (0.58) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL11241141 | 0.77 | KMT2A (0.47) | L3MBTL1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL10749843 | 0.77 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL7639935 | 0.76 | TSHR (0.60) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL11337474 | 0.76 | HTR7 (0.56) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL26204404 | 0.75 | ALDH1A1 (0.58) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL7795191 | 0.74 | ALDH1A1 (0.66) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL14365499 | 0.73 | TP53 (0.54) | ALDH1A1KDM4EMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107320-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |
| EP-0680472-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014673-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA S.P.A. (IT) | 1995-06-01 | — | — | WO | disclosed |