Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749627 | 0.84 | MAPT (0.47) | HDAC2HDAC1GPR119KMT2ALMNA | |
| SCHEMBL4746323 | 0.83 | HDAC1 (0.40) | HDAC2HDAC1 | |
| SCHEMBL606031 | 0.79 | ALDH1A1 (0.55) | HDAC2HDAC1GPR119KMT2ALMNA | |
| SCHEMBL4566835 | 0.75 | SMARCA2 (0.54) | GPR119KMT2ALMNACYP2C19MEN1 | |
| SCHEMBL31170973 | 0.75 | POLB (0.50) | HDAC2HDAC1GPR119PIK3CDPIK3R1 | |
| SCHEMBL29124518 | 0.75 | POLB (0.50) | HDAC2HDAC1GPR119PIK3CDPIK3R1 | |
| SCHEMBL4746151 | 0.75 | HDAC1 (0.50) | HDAC2HDAC1GPR119KMT2ALMNA | |
| SCHEMBL27029906 | 0.75 | NAMPT (0.43) | HDAC2HDAC1GPR119KMT2AMEN1 | |
| SCHEMBL2596267 | 0.74 | HDAC2 (0.56) | HDAC2HDAC1KMT2ALMNANPSR1 | |
| SCHEMBL26442434 | 0.74 | GPR119 (0.47) | HDAC2HDAC1GPR119KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119718-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |