Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788788 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTLMNAMAPK1RAF1 | |
| SCHEMBL4750375 | 0.79 | KDM4E (0.51) | SMN1; SMN2MAPTLMNAMAPK1RAF1 | |
| SCHEMBL4750374 | 0.72 | MAPT (0.49) | SMN1; SMN2MAPTLMNAMAPK1RAF1 | |
| SCHEMBL16318456 | 0.65 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLMNAMAPK1RAF1 | |
| SCHEMBL18424682 | 0.64 | KDM4E (0.63) | SMN1; SMN2MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL4786387 | 0.64 | LMNA (0.54) | SMN1; SMN2MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL4750453 | 0.63 | KDM4E (0.55) | SMN1; SMN2MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL4750033 | 0.62 | KDM4E (0.62) | SMN1; SMN2MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL1728020 | 0.62 | KMT2A (0.60) | SMN1; SMN2MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL12171678 | 0.62 | AR (0.54) | SMN1; SMN2MAPTLMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |