Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | PHGDH | O43175 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726841 | 0.93 | PHGDH (0.60) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1728487 | 0.91 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1726833 | 0.86 | KDM4A (0.60) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1727760 | 0.83 | MEN1 (0.44) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1727655 | 0.80 | SMN1; SMN2 (0.59) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1728489 | 0.79 | KDM4A (0.62) | SMN1; SMN2MAPTLMNAUSP2KDM4E | |
| SCHEMBL1728185 | 0.79 | MAPT (0.55) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1728252 | 0.78 | ADORA3 (0.63) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1726609 | 0.77 | MAPT (0.54) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1726674 | 0.77 | NPC1 (0.52) | KMT2AMEN1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |