Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749875 | 0.89 | MAPT (0.56) | RORCMAPTMAPK1ROCK1PRKACA | |
| SCHEMBL4750359 | 0.87 | KMT2A (0.60) | RORCL3MBTL1MAPTMAPK1KDM4E | |
| SCHEMBL4750943 | 0.87 | MAPK1 (0.63) | RORCMAPTMAPK1ROCK1PRKACA | |
| SCHEMBL4750765 | 0.85 | KMT2A (0.56) | RORCMAPTMAPK1ROCK1PRKACA | |
| SCHEMBL4747401 | 0.83 | MAPT (0.67) | MAPTMAPK1ROCK1KDM4EUSP2 | |
| SCHEMBL4786428 | 0.83 | RAB9A (0.67) | MAPTROCK1KDM4ETSHRMEN1 | |
| SCHEMBL4750837 | 0.83 | MAPK1 (0.49) | RORCMAPTMAPK1KDM4EUSP2 | |
| SCHEMBL4746879 | 0.81 | SMN1; SMN2 (0.46) | RORCL3MBTL1MAPTMAPK1KDM4E | |
| SCHEMBL4747425 | 0.81 | SLC2A1 (0.44) | RORCMAPTMAPK1KDM4EUSP2 | |
| SCHEMBL4746882 | 0.80 | SMN1; SMN2 (0.47) | RORCMAPTMAPK1ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |