Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750453 | 0.88 | KDM4E (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4785744 | 0.87 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL4746882 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL14041926 | 0.84 | KDM4E (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4750765 | 0.82 | KMT2A (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4786428 | 0.82 | RAB9A (0.67) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4750943 | 0.82 | MAPK1 (0.63) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4786387 | 0.82 | LMNA (0.54) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4746954 | 0.81 | ABL1 (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4788490 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |