Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.50 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747401 | 0.90 | MAPT (0.67) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4746954 | 0.89 | ABL1 (0.52) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4750359 | 0.85 | KMT2A (0.60) | MAPTMAPK1RAB9ASMN1; SMN2HTT | |
| SCHEMBL4750943 | 0.84 | MAPK1 (0.63) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4750765 | 0.83 | KMT2A (0.56) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4786428 | 0.81 | RAB9A (0.67) | MAPTRAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL4750837 | 0.81 | MAPK1 (0.49) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4746879 | 0.79 | SMN1; SMN2 (0.46) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4747425 | 0.79 | SLC2A1 (0.44) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4746882 | 0.78 | SMN1; SMN2 (0.47) | MAPTMAPK1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |