Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | DDO | Q99489 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745410 | 0.85 | RXFP1 (0.69) | RXFP1KDM4EHSD17B10USP2ALDH1A1 | |
| SCHEMBL4746065 | 0.83 | RXFP1 (0.57) | RXFP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL4743044 | 0.82 | RXFP1 (0.56) | RXFP1KDM4EHSD17B10ALDH1A1TAAR1 | |
| SCHEMBL4743608 | 0.79 | RXFP1 (0.53) | RXFP1KDM4EHSD17B10USP2ALDH1A1 | |
| SCHEMBL14068682 | 0.78 | HSD17B10 (0.61) | KDM4EHSD17B10USP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4072838 | 0.76 | KDM4E (0.61) | RXFP1KDM4EHSD17B10USP2ALDH1A1 | |
| SCHEMBL26096928 | 0.76 | NSD2 (0.57) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24970979 | 0.75 | DAO (0.65) | RXFP1KDM4EHSD17B10USP2ALDH1A1 | |
| SCHEMBL5460835 | 0.74 | KDM4E (0.57) | RXFP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL17505178 | 0.73 | KDM4E (0.61) | RXFP1KDM4EHSD17B10USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | claimed |
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008113006-A1 | METHODS OF USING QUINOLINONE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-18 | — | — | WO | disclosed |