Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819626 | 0.81 | DRD2 (0.40) | ADRA2CHRH4DRD2DRD3DRD1 | |
| SCHEMBL6819614 | 0.81 | DRD2 (0.40) | ADRA2CHRH4DRD2DRD3DRD1 | |
| SCHEMBL6930432 | 0.78 | ALDH1A1 (0.43) | DRD2DRD3DRD1DRD4HTR2A | |
| SCHEMBL6930424 | 0.78 | ALDH1A1 (0.43) | DRD2DRD3DRD1DRD4HTR2A | |
| SCHEMBL14157834 | 0.74 | KCNH2 (0.47) | ADRA2CDRD2DRD3DRD4HTR2A | |
| SCHEMBL4751796 | 0.74 | KCNH2 (0.47) | ADRA2CDRD2DRD3DRD4HTR2A | |
| SCHEMBL4834468 | 0.74 | KCNH2 (0.47) | ADRA2CDRD2DRD3DRD4HTR2A | |
| SCHEMBL4838068 | 0.74 | KCNH2 (0.47) | ADRA2CDRD2DRD3DRD4HTR2A | |
| SCHEMBL17987100 | 0.67 | HTR1A (0.62) | ADRA2CHRH4DRD2DRD3HTR2A | |
| SCHEMBL328223 | 0.66 | MAPT (0.58) | ADRA2CHRH4NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |