Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930424 | 1.00 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10DRD2DRD4 | |
| SCHEMBL6819626 | 0.81 | DRD2 (0.40) | ALDH1A1KDM4EHSD17B10DRD2DRD4 | |
| SCHEMBL6819614 | 0.81 | DRD2 (0.40) | ALDH1A1KDM4EHSD17B10DRD2DRD4 | |
| SCHEMBL4747515 | 0.78 | ADRA2C (0.38) | DRD2DRD4DRD3HTR2ADRD1 | |
| SCHEMBL6933310 | 0.78 | HTR1A (0.38) | ALDH1A1KDM4EHSD17B10DRD2HTT | |
| SCHEMBL6932653 | 0.77 | PARP1 (0.42) | ALDH1A1KDM4EHSD17B10DRD2DRD4 | |
| SCHEMBL6932658 | 0.77 | PARP1 (0.42) | ALDH1A1KDM4EHSD17B10DRD2DRD4 | |
| SCHEMBL6932616 | 0.76 | KCNH2 (0.51) | ALDH1A1KDM4EHSD17B10DRD2DRD3 | |
| SCHEMBL6932612 | 0.76 | KCNH2 (0.51) | ALDH1A1KDM4EHSD17B10DRD2DRD3 | |
| SCHEMBL5760421 | 0.75 | HTR1A (0.51) | PARP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| US-6387899-B1 | ANTISEROTONINE AGENTS; ANTIDEPRESSANTS | ASTRAZENECA AB (SE) | 2002-05-14 | — | — | US | disclosed |
| US-6384225-B1 | 5-PIPERIDINYL- OR PIPERAZINYL-SUBSTITUTED 3,4-DIHYDRO-2H-1-BENZOPYRANS | ASTRAZENECA AB (SE) | 2002-05-07 | — | — | US | disclosed |