Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | ALPL | P05186 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981910 | 0.84 | KMT2A (0.78) | GAAKMT2AHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4743368 | 0.83 | GAA (0.62) | GAASMN1; SMN2ALPLKMT2AHSD17B10 | |
| SCHEMBL4745522 | 0.83 | MEN1 (0.59) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL8762392 | 0.80 | LMNA (0.65) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL15486152 | 0.74 | NPC1 (0.59) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL14019207 | 0.74 | SMN1; SMN2 (0.67) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL9430964 | 0.73 | NPC1 (0.58) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL18193849 | 0.73 | GAA (0.57) | GAASMN1; SMN2KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL8631029 | 0.73 | NPC1 (0.58) | GAASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL3919648 | 0.73 | KMT2A (0.60) | GAASMN1; SMN2KMT2AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107677-A2 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SENEXIS LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |