Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | ALPL | P05186 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747655 | 0.83 | GAA (0.58) | GAAALPLTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL31558731 | 0.82 | KMT2A (0.72) | GAAALPLPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL255251 | 0.81 | GAA (0.76) | GAAPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL11298577 | 0.79 | RAB9A (0.75) | GAAALPLPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5592711 | 0.78 | RAB9A (0.58) | GAASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL10480392 | 0.78 | GAA (0.81) | GAAALPLPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4046696 | 0.77 | KMT2A (0.69) | GAAPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL9220486 | 0.76 | RAB9A (0.67) | GAAPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL11652211 | 0.76 | KMT2A (0.67) | GAAPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL13593757 | 0.74 | POLB (0.55) | GAAPOLBSMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107677-A2 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SENEXIS LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |