Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350694 | 0.84 | L3MBTL1 (0.69) | MEN1KMT2ACYP2C19L3MBTL1NPC1 | |
| SCHEMBL4747655 | 0.83 | GAA (0.58) | MEN1KMT2ACYP2C19CYP1A2NPC1 | |
| SCHEMBL8762392 | 0.81 | LMNA (0.65) | MEN1KMT2ACYP2C19CYP1A2NPC1 | |
| SCHEMBL9430964 | 0.77 | NPC1 (0.58) | MEN1KMT2ACYP2C19CYP1A2NPC1 | |
| SCHEMBL17141787 | 0.76 | HDAC2 (0.70) | SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL7459472 | 0.76 | SMN1; SMN2 (0.79) | L3MBTL1GAAALDH1A1KDM4EHTT | |
| SCHEMBL14019207 | 0.75 | SMN1; SMN2 (0.67) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL28445081 | 0.75 | ALDH1A1 (0.51) | MEN1KMT2ACYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL31475190 | 0.75 | HDAC1 (0.62) | MEN1KMT2ACYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL7217481 | 0.75 | HDAC1 (0.62) | MEN1KMT2ACYP2C19CYP1A2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107677-A2 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SENEXIS LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |