Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064222 | 0.88 | GRM5 (0.45) | MAPK1GRM5ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4072415 | 0.83 | KDM4E (0.42) | MAPK1GRM5ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4750277 | 0.74 | PNMT (0.42) | GRM5ALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL4062579 | 0.72 | PDE4B (0.56) | — | |
| SCHEMBL28708196 | 0.72 | MAPK1 (0.56) | MAPK1ALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL4066864 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KDM4ESMN1; SMN2KMT2ATP53 | |
| SCHEMBL29713571 | 0.72 | MAPK1 (0.56) | MAPK1ALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL13626332 | 0.69 | HRH3 (0.54) | GRM5HRH3HTT | |
| SCHEMBL4747756 | 0.68 | HRH3 (0.39) | ALDH1A1KDM4ESMN1; SMN2HRH3HPGD | |
| SCHEMBL29713565 | 0.67 | MAPT (0.53) | ALDH1A1KDM4ESMN1; SMN2KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | disclosed |