Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TYMS | P04818 | 1/20 | 0.62 |
| ▸ | POLA1 | P09884 | 1/20 | 0.58 |
| ▸ | POLD1 | P28340 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30583236 | 1.00 | TK1 (0.77) | TK1POLBTYMSPOLA1POLD1 | |
| SCHEMBL7192376 | 0.90 | POLB (0.73) | TK1POLBTYMSPOLA1POLD1 | |
| Thymidine Monophosphate SCHEMBL18785041 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL2037921 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL16092807 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL7876022 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL8366987 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL16280929 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL3984895 | 0.88 | POLB (0.80) | TK1POLBTYMS | |
| Thymidine Monophosphate SCHEMBL21257 | 0.88 | POLB (0.80) | TK1POLBTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791056-B1 | LIPID-CLEAVAGE ENZYME COMPLEX | HEIDELBERG PHARMA GMBH (DE) | 2005-03-30 | — | — | EP | claimed |
| US-20030082167-A1 | Lapid cleavage enzyme | HEIDELBERG PHARMA HOLDING GMBH | 2003-05-01 | — | — | US | claimed |
| US-5563257-A | Phospholipid derivatives of nucleosides | BOEHRINGER MANNHEIM GMBH (DE) | 1996-10-08 | — | — | US | claimed |
| EP-0545966-B1 | NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS ANTIVIRAL DRUGS | BOEHRINGER MANNHEIM GMBH (DE) | 1994-11-23 | — | — | EP | claimed |
| US-20080249066-A1 | ANTIVIRAL COMPOUNDS AND COMPOSITIONS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| WO-2008118879-A2 | ANTIVIRAL COMPOSITIONS COMPRISING 2 COMPOUNDS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| US-7176011-B2 | Lipid cleavage enzyme | HEIDELBERG PHARMA AG (DE) | 2007-02-13 | — | — | US | disclosed |
| EP-0791056-B1 | LIPID-CLEAVAGE ENZYME COMPLEX | HEIDELBERG PHARMA GMBH (DE) | 2005-03-30 | — | — | EP | disclosed |
| US-20030082167-A1 | Lapid cleavage enzyme | HEIDELBERG PHARMA HOLDING GMBH | 2003-05-01 | — | — | US | disclosed |
| US-20020122817-A1 | SOLID INSTANT-RELEASE FORMS OF ADMINISTRATION AND PROCESS FOR PRODUCING THE SAME | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2002-09-05 | — | — | US | disclosed |
| US-20020106363-A1 | LIPID CLEAVAGE ENZYME | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2002-08-08 | — | — | US | disclosed |
| US-6372725-B1 | VIRICIDES, ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2002-04-16 | — | — | US | disclosed |
| EP-0817790-B1 | SPECIFIC LIPID CONJUGATES OF NUCLEOSIDE DIPHOSPHATES AND THEIR USE AS DRUGS | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2001-11-14 | — | — | EP | disclosed |
| US-5756711-A | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1998-05-26 | — | — | US | disclosed |
| EP-0791056-A2 | LIPID-SPLITTING ENZYME | Roche Diagnostics GmbH (DE) | 1997-08-27 | — | — | EP | disclosed |
| US-5563257-A | Phospholipid derivatives of nucleosides | BOEHRINGER MANNHEIM GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| WO-1996015234-A2 | LIPID-SPLITTING ENZYME | BOEHRINGER MANNHEIM GMBH (DE) | 1996-05-23 | — | — | WO | disclosed |
| US-5153180-A | Used for treating aids | BURROUGHS WELLCOME CO. | 1992-10-06 | — | — | US | disclosed |
| US-4963662-A | Fluorinated nucleosides and method for treating retrovirus infections therewith | AKADEMIE DER WISSENSCHAFTEN DER DDR (DD) | 1990-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249066-A1 | ANTIVIRAL COMPOUNDS AND COMPOSITIONS | PNP, TYMP, MTAP | TK1 114/4885POLB 46/4885TYMS 17/4885 |
| US-20030082167-A1 | Lapid cleavage enzyme | LAP3, NAALAD2, ENGASE | TK1 975/4885POLB 3644/4885TYMS 2654/4885 |
| US-20020122817-A1 | SOLID INSTANT-RELEASE FORMS OF ADMINISTRATION AND PROCESS FOR PRODUCING THE SAME | ADAR, PAICS, GART | TK1 17/4885POLB 2676/4885TYMS 212/4885 |
| US-20020106363-A1 | LIPID CLEAVAGE ENZYME | SMPD1, MMEL1, ENGASE | TK1 689/4885POLB 2942/4885TYMS 1809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.