Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 11/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650004 | 0.88 | CCR2 (0.54) | CCR2PLA2G2A | |
| SCHEMBL4650663 | 0.87 | CCR2 (0.55) | CCR2PLA2G2APTGER4 | |
| SCHEMBL4650169 | 0.84 | CCR9 (0.55) | CCR2 | |
| SCHEMBL4648818 | 0.84 | CCR2 (0.53) | CCR2PPARG | |
| SCHEMBL4649957 | 0.83 | CCR2 (0.53) | CCR2PLA2G2APTGER4 | |
| SCHEMBL4807606 | 0.81 | CCR2 (0.51) | CCR2PTGER4 | |
| SCHEMBL4649909 | 0.80 | CCR2 (0.50) | CCR2PTGER4 | |
| SCHEMBL4653137 | 0.78 | CCR2 (0.47) | CCR2PTGER4PPARG | |
| SCHEMBL4649594 | 0.77 | CCR2 (0.48) | PTGESCCR2PPARG | |
| SCHEMBL4652792 | 0.76 | CCR2 (0.49) | CCR2PLA2G2APPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |