Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026512 | 0.89 | NPC1 (0.41) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4779145 | 0.86 | MC4R (0.40) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4779138 | 0.86 | MC4R (0.40) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4021139 | 0.84 | KDM2B (0.43) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4022303 | 0.81 | KDM2B (0.34) | MC4RKCNH2KDM2B | |
| SCHEMBL4020496 | 0.81 | DRD4 (0.34) | CYP2C9KDM2B | |
| SCHEMBL4021775 | 0.80 | NPC1 (0.35) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4780053 | 0.80 | MC4R (0.44) | NPC1MC4RF10NTRK1 | |
| SCHEMBL4749411 | 0.80 | KDM2B (0.33) | NPC1TNFRAB9ANOD1MC4R | |
| SCHEMBL4749418 | 0.80 | KDM2B (0.33) | NPC1TNFRAB9ANOD1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |