Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603516 | 0.94 | OPRM1 (0.59) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL4749322 | 0.88 | OPRM1 (0.45) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL29848371 | 0.86 | ALDH1A1 (0.48) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL29848373 | 0.86 | ALDH1A1 (0.48) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL5956482 | 0.86 | CCR5 (0.60) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL29198147 | 0.85 | CHRM1 (0.53) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL14041658 | 0.83 | CHRM1 (0.50) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL3414103 | 0.82 | CCR5 (0.49) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL8710318 | 0.82 | CHRM1 (0.51) | OPRM1OPRD1OPRK1CHRM1CHRM2 | |
| SCHEMBL31192530 | 0.82 | CHRM1 (0.51) | OPRM1OPRD1OPRK1CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |