Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.51 |
| ▸ | CCR5 | P51681 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.51 |
| ▸ | PLD2 | O14939 | 4/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31192530 | 1.00 | CHRM1 (0.51) | CHRM1CCR5DRD2HSD11B1PLD2 | |
| SCHEMBL8047936 | 0.92 | HSD11B1 (0.60) | CHRM1CCR5DRD2HSD11B1PLD2 | |
| SCHEMBL30870565 | 0.92 | HSD11B1 (0.60) | CHRM1CCR5DRD2HSD11B1PLD2 | |
| SCHEMBL603516 | 0.88 | OPRM1 (0.59) | CHRM1CCR5HSD11B1CHRM2CHRM4 | |
| SCHEMBL22605673 | 0.88 | HSD11B1 (0.56) | CHRM1CCR5HSD11B1CHRM2CHRM4 | |
| SCHEMBL28706667 | 0.87 | OPRM1 (0.57) | CHRM1CCR5HSD11B1PLD2PLD1 | |
| SCHEMBL4636659 | 0.87 | OPRM1 (0.53) | CHRM1CCR5DRD2HSD11B1CHRM2 | |
| SCHEMBL20599032 | 0.87 | CCR5 (0.49) | CHRM1CCR5HSD11B1CHRM2CHRM4 | |
| SCHEMBL22587914 | 0.86 | HSD11B1 (0.56) | CHRM1CCR5DRD2HSD11B1CHRM2 | |
| SCHEMBL4667693 | 0.86 | CCR5 (0.51) | CHRM1CCR5HSD11B1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113924296-A | 1,3, 4-oxadiazole derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same | 株式会社钟根堂 | 2022-01-11 | — | — | CN | disclosed |
| WO-2020240492-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-12-03 | — | — | WO | disclosed |
| EP-0812196-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0812196-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1997-12-17 | — | — | EP | disclosed |