Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4894210 | 1.00 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714109 | 0.80 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714110 | 0.80 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7180535 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7173330 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6119092 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7175502 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7183213 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7175999 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4887030 | 0.73 | ALDH1A1 (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269266-A1 | NOVEL COMPOUNDS 747 | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
| WO-2008117051-A1 | S-6-METH0XY-2- (2- (3- (PYRIMID-2-YL) IS0XAZ0L-5-YL) PYRROLIDIN-1-YL) -4- (5-METHYL-IH-PYRAZOL-S-YLAMINO) PYRIMIDINE AND POLYMORPHIC FORMS THEREOF AS MODULATORS OF THE INSULIN-LIKE GROWTH | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269266-A1 | NOVEL COMPOUNDS 747 | UGT2B7, UGT1A7, CYP3A7 | ALDH1A1 790/4885ALOX15 3906/4885RAB9A 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.