Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022030 | 1.00 | POLB (0.49) | POLBTSHRGABRA1GABRB2MAPT | |
| SCHEMBL14022792 | 0.77 | LMNA (0.47) | POLBMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14022031 | 0.77 | LMNA (0.47) | POLBMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14021983 | 0.76 | MAPT (0.47) | POLBTSHRGABRA1GABRB2MAPT | |
| SCHEMBL10816776 | 0.74 | POLB (0.38) | POLBTSHRGABRA1GABRB2MAPT | |
| SCHEMBL4135919 | 0.74 | POLB (0.62) | POLBTSHRGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL335140 | 0.72 | POLB (0.60) | POLBTSHRGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL22103746 | 0.72 | POLB (0.55) | POLBTSHRGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL14021980 | 0.71 | GAA (0.39) | POLBMAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL2756366 | 0.71 | RAPGEF4 (0.57) | MAPTGAARAPGEF4FFAR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135386-A1 | CHIRAL LIGANDS OF THE N-HETEROCYCLIC CARBENE TYPE FOR ASYMMETRICAL CATALYSIS | ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES (FR) | 2008-11-13 | — | — | WO | disclosed |